The Challenges

TMVR poses new challenges in comparison with TAVI:

• Robust anchoring of the valve to the native annulus

• Implantation in a minimally invasive approach - transcatheter

• Creation of a simple and safe procedure

• Elimination of paravalvular leaks (PVL)

• Elimination of Left Ventricular Outflow Tract (LVOT) obstruction

• Minimization of disturbance to the cardiac structure

• Large valve area and high work blood pressures

• Valve prosthesis durability

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